The Resident Evil 5 trailer is up at gametrailers.com. I suppose the inevitable strike against it is that the gameplay doesn't look any different from RE4, and even though that's not a bad thing in itself, you always hope for a big leap forward. Then again, it took several years for the original Resident Evil style to get stale (I didn't get tired of it until Zero, which was the last one before RE4). I can certainly take another game in the vein of RE4.
Additionally, I greatly enjoyed the unexpected face punch in this trailer, and I can only hope that I will get to do plenty of face punching once I'm finally playing the game.